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[Effect of Helicteres angustifolia on rats with ulcerative colitis]
1Zhongshan Hospital, Guangzhou University of TCM, Zhongshan 528400, China. aqiaosky@163.com
Objective:
To investigate the effect of aqueous extract of Helicteres angustifolia (AEHA) on rats with ulcerative colitis (UC) and its mechanism.
Methods:
SD rats were randomly divided into 6 groups normal control group, the model group, SASP group and 21.6, 10.8, 5.4 g/kg AEHA group with 10 rats in each group. UC was induced by clyster with 2, 4,6-trinitrobenzesulphonic acid (TN-BS) in rats. Rats were given AEHA by gavage for 3 weeks, and sacrificed at day 22nd to determine the expressions of IL-10, IL-6 and TNF-alpha in blood. Colon tissue pathological changes were investigated.
Results:
Compared with the control group, the expression of IL-10 was increased, the expressions of IL-6 and TNF-alpha were decreased in AEHA treatment groups. The colon tissue damages and the symptoms of UC rats were improved.
Conclusion:
AEHA can keep balance of inflammatory factors in blood of UC rats, and improve it's colon tissue damages and symptoms.
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