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Updated: May 6, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Eruptive squamous cell carcinomas after vemurafenib therapy
Vemurafenib treatment for cancer can cause skin issues like squamous cell carcinoma (SCC) and actinic keratosis (AK). A combination of isotretinoin and 5-fluorouracil may prevent these side effects.
Area of Science:
- Oncology
- Dermatology
Background:
- Vemurafenib is an oral BRAF inhibitor used for metastatic melanoma.
- Patients on vemurafenib may develop squamous cell carcinoma (SCC) and actinic keratosis (AK).
Observation:
- A patient treated with vemurafenib for papillary thyroid carcinoma developed multiple SCCs and AK.
- These skin lesions were attributed to vemurafenib and treated with excision.
Findings:
- Subsequent development of SCCs and AK was prevented by a combination of isotretinoin and 5-fluorouracil.
- This suggests a potential preventive strategy for vemurafenib-associated skin conditions.
Implications:
- Understanding the mechanisms behind vemurafenib-induced skin cancers is crucial.
- Combination therapy with isotretinoin and 5-fluorouracil may offer a preventive approach for patients on vemurafenib.
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