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Antioxidant properties of pyrrolobenzimidazole derivative RU-792: experimental study
V A Kosolapov1, L V Eltsova, A A Spasov
1Department of Pharmacology, Volgograd State Medical Academy; Laboratory of Pharmacology of Antioxidant Substances, Institute of Pharmacology, Volgograd State Medical Academy; Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia. vad-ak@mail.ru.
Abstract:
We studied antioxidant activity of new derivative of pyrrolo[1,2-α]benzimidazole RU-792 and compared its effects on free radical processes with those of the reference antioxidant Trolox in four model free-radical systems. RU-792 had high antioxidant activity determined by its intrinsic antiradical properties. RU-792 was superior to Trolox by antioxidant activity in the models of Fe(2+)-induced chemiluminescence of lipids with 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid), but less effective in the model of luminol-dependent chemiluminescence.
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