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Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Updated: May 6, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

A sugar-based phase-transitioning delivery system for bone tissue engineering.

T L Cheng¹, P Valtchev, C M Murphy

¹Orthopaedic Research & Biotechnology, Research Building, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145, Australia.tegan.cheng@sydney.edu.au.

European Cells & Materials

|October 23, 2013

Summary

This summary is machine-generated.

Injectable sucrose acetate isobutyrate (SAIB) offers a less invasive carrier for bone morphogenetic proteins (rhBMPs). Combining SAIB with zoledronic acid and hydroxyapatite significantly enhanced bone volume in tissue engineering.

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Area of Science:

Biomaterials Science
Regenerative Medicine
Orthopedic Research

Background:

Bone tissue engineering frequently utilizes recombinant human bone morphogenetic proteins (rhBMPs).
Current rhBMP carriers, like collagen sponges, require surgical implantation, increasing infection risks.
An injectable carrier system for rhBMPs could minimize surgical invasiveness and infection potential.

Purpose of the Study:

To evaluate sucrose acetate isobutyrate (SAIB) as an injectable carrier for rhBMP-2 in bone regeneration.
To optimize the SAIB/rhBMP-2 formulation by incorporating additives like ceramic microparticles and anti-resorptives.
To investigate the synergistic effects of zoledronic acid (ZA) and hydroxyapatite (HA) within the SAIB/rhBMP-2 system.

Main Methods:

Ectopic bone formation model in C57BL6/J mice.
Non-invasive delivery of SAIB/rhBMP-2 formulations.
Assessment via X-ray, microCT, and histology at 3 weeks.
In vitro binding assays and in vivo biodistribution studies to elucidate mechanisms.

Main Results:

SAIB alone demonstrated a 3-fold increase in bone volume compared to collagen carriers.
A formulation of SAIB/rhBMP-2 with zoledronic acid (ZA) and hydroxyapatite (HA) microparticles yielded a 10-fold greater bone volume.
Ceramic particles were shown to bind and sequester ZA, suggesting a mechanism for enhanced efficacy.

Conclusions:

SAIB is a viable, non-invasive delivery system for rhBMPs in bone tissue engineering.
The combination of SAIB, rhBMP-2, ZA, and HA represents an optimized formulation for enhanced bone regeneration.
Understanding particle-drug interactions is crucial for developing advanced biomaterial delivery systems.