Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...

Mechanism of Angiogenesis

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Towards a cultivated ribeye.

Trends in biotechnology·2025

Same author

Process intensification of cultivated meat production through microcarrier addition strategy optimisation.

Scientific reports·2025

Same author

Attachment promoting compounds significantly enhance cell proliferation and purity of bovine satellite cells grown on microcarriers in the absence of serum.

Frontiers in bioengineering and biotechnology·2024

Same author

Optimisation of cell fate determination for cultivated muscle differentiation.

Communications biology·2024

Same author

Additive Anticonvulsive Effects of Sumatriptan and Morphine on Pentylenetetrazole-Induced Clonic Seizures in Mice.

Journal of epilepsy research·2024

Same author

Short-Stranded Zein Fibers for Muscle Tissue Engineering in Alginate-Based Composite Hydrogels.

Gels (Basel, Switzerland)·2023

Same journal

Industry updates in advanced therapy medicinal products and regenerative medicine - May 2026.

Regenerative medicine·2026

Same journal

Ethical, legal, and social issues associated with human fetal tissue research in Japan.

Regenerative medicine·2026

Same journal

The future of hematopoietic stem cell and stem cell gene therapy for metabolic diseases.

Regenerative medicine·2026

Same journal

Exploring gene therapy for developmental and epileptic encephalopathies (DEEs): possibilities or promises?

Regenerative medicine·2026

Same journal

Industry updates in advanced therapy medicinal products and regenerative medicine - April 2026.

Regenerative medicine·2026

Same journal

Optimizing strategies in tendon tissue engineering through effective scaffold design: overview of recent advancements.

Regenerative medicine·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 6, 2026

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

Published on: August 28, 2014

Update on vascularization in tissue engineering.

Mark J Post¹, Nastaran Rahimi, Vincenza Caolo

¹Department of Physiology, Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.

Regenerative Medicine

|October 24, 2013

Summary

This summary is machine-generated.

Engineered tissue success hinges on vascularization. Pre-formed vascular networks in scaffolds are crucial for large or high-metabolism tissues, while smaller tissues may benefit from host vessel ingrowth.

More Related Videos

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels

Published on: January 14, 2021

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Published on: May 30, 2016

Related Experiment Videos

Last Updated: May 6, 2026

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

Published on: August 28, 2014

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels

Published on: January 14, 2021

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Published on: May 30, 2016

Area of Science:

Biomedical Engineering
Regenerative Medicine
Tissue Engineering

Background:

Vascularization is essential for engineered tissue viability and function.
Adequate blood supply supports parenchymal cell function, a key goal in regenerative medicine.
Current methods focus on stimulating revascularization for tissue implantation.

Purpose of the Study:

To highlight the critical role of vascularization in engineered tissues.
To discuss strategies for achieving adequate blood supply in engineered tissues.
To differentiate requirements for large vs. small engineered tissues.

Main Methods:

Review of strategies for stimulating revascularization in engineered tissues.
Discussion of prevascularized scaffolds with hierarchical vascular patterns.
Consideration of pre-seeding scaffolds with vascular cells or precursors.

Main Results:

Prevascularized scaffolds with surgical hook-up capability are needed for large or high-metabolism tissues like myocardium.
Pre-implantation mature vasculature enhances parenchyma differentiation and maturation.
Smaller or less-metabolically active tissues may rely on host vasculature ingrowth post-implantation.

Conclusions:

Engineered tissue vascularization is critical for clinical success.
Pre-formed vascular networks are vital for specific tissue types.
Both pre-implantation vascularization and facilitated host ingrowth are important strategies.