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3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds
Published on: April 24, 2019
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Injectable 3D hydrogel scaffold with tailorable porosity post-implantation
Aswan Al-Abboodi1, Jing Fu, Pauline M Doran
1Department of Chemical Engineering, Monash University, Clayton, 3800, Australia.
Advanced Healthcare Materials
|October 24, 2013
Summary
This study introduces a novel hydrogel scaffold that allows pore size adjustment after implantation. This innovation enables personalized tissue engineering by adapting to individual healing rates.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Tissue growth rates vary significantly, posing challenges for personalized tissue engineering scaffolds.
- Existing scaffolds lack adaptability to individual patient needs and healing processes.
Purpose of the Study:
- To develop an adaptable hydrogel scaffold system for personalized tissue engineering.
- To enable in vivo modification of scaffold pore structure post-implantation.
Main Methods:
- A gelatin-hydroxyphenylpropionic acid/carboxylmethylcellulose-tyramine (Gtn-HPA/CMC-Tyr) hydrogel was synthesized.
- In vitro and in vivo cross-linking using horseradish peroxidase was assessed.
- In vivo pore size modification was achieved by enzymatic digestion of the CMC component using cellulase.
Main Results:
- The Gtn-HPA/CMC-Tyr hydrogel system demonstrated successful in vivo cross-linking.
- Enzymatic treatment with cellulase significantly increased scaffold pore size and porosity (from 32-87 μm to 74-181 μm).
- The hydrogel exhibited biocompatibility with COS-7 cells and mechanical properties suitable for soft tissues.
Conclusions:
- The developed hydrogel system allows user-controlled, in vivo alteration of scaffold structure.
- This adaptability makes the hydrogel system highly suitable for personalized tissue engineering applications.
- Clinicians can tailor scaffolds to individual tissue growth and recovery rates.
