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Transepithelial elimination in sarcoidosis: a frequent finding
Aimen Ismail1, Kathleen Beckum, Kristopher McKay
1School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Journal of Cutaneous Pathology
|October 25, 2013
Summary
Transepithelial elimination, a process of dermal material expulsion, was observed in 18% of cutaneous sarcoidosis cases. This finding suggests transepithelial elimination is more common in sarcoidosis than previously reported.
Area of Science:
- Dermatology
- Pathology
- Histology
Background:
- Transepithelial elimination involves dermal material expulsion via epithelial-dermal interaction.
- This process is observed in various dermatologic conditions, including sarcoidosis.
Observation:
- A rare case of genital sarcoidosis with histopathologic evidence of transepithelial elimination of granulomas was identified.
- This led to a case series investigating the frequency of transepithelial elimination in cutaneous sarcoidosis.
Findings:
- Transepithelial elimination was identified in 9 out of 50 (18%) cutaneous sarcoidosis biopsies.
- The study defined transepithelial elimination by epithelial channel formation surrounding granulomas.
Implications:
- This research is the first to report transepithelial elimination in vulvar sarcoidosis.
- The findings suggest transepithelial elimination is a more frequent occurrence in cutaneous sarcoidosis than the current literature indicates.
