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Low level laser therapy on experimental myopathy.

Soledad Dávila¹, María Belén Vignola, David Cremonezzi

¹Cátedra de Física Biomédica. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Santa Rosa 1085. (5000) Córdoba, Argentina.

|October 25, 2013

Summary

Low Level Laser Therapy (LLLT) with Helium-Neon (HeNe) and Gallium Arsenide (GaAs) lasers reduced nitric oxide (NO) levels in rats with experimental myopathy, promoting muscle recovery and reducing inflammation.

Keywords:

Gallium Arsenide Helium Neon LLLT myopathy nitric oxide

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Area of Science:

Biomedical Engineering
Regenerative Medicine
Inflammation Research

Background:

Myopathy involves muscle damage and inflammation, often associated with increased oxidative stress and nitric oxide (NO) levels.
Nitric oxide (NO) is a key inflammatory biomarker implicated in the pathogenesis of various muscle disorders.
Low Level Laser Therapy (LLLT) is explored for its potential therapeutic effects in tissue repair and inflammation modulation.

Purpose of the Study:

To investigate the impact of Helium-Neon (HeNe) and Gallium Arsenide (GaAs) laser therapy on plasma nitric oxide (NO) levels in rats with experimentally induced myopathy.
To evaluate the efficacy of LLLT in mitigating inflammation and promoting muscle recovery through histological assessment.

Main Methods:

Experimental myopathy was induced in rats via carrageenan injection into the gastrocnemius muscle.
Rats were divided into groups: control, myopathy-induced (sacrificed at different time points), and myopathy-induced treated with HeNe or GaAs laser.
Low Level Laser Therapy (LLLT) was administered daily for 10 days. Nitric oxide (NO) levels were measured spectrophotometrically, and muscle tissues were analyzed histologically.

Main Results:

Significantly elevated plasma NO levels were observed in myopathic rats compared to control and LLLT-treated groups.
Histological analysis revealed a marked increase in inflammatory infiltration in untreated myopathic muscle tissue, particularly at later time points.
LLLT treatment demonstrated a reduction in NO levels and appeared to facilitate muscle recovery, as indicated by reduced inflammation.

Conclusions:

LLLT, using both HeNe and GaAs lasers, effectively reduces elevated plasma nitric oxide (NO) levels in experimental myopathy models.
The findings suggest that LLLT promotes significant muscle recovery and mitigates inflammation in myopathic conditions.
LLLT holds promise as a therapeutic modality for managing inflammatory myopathies by modulating NO pathways.