Related Experiment Video
Updated: May 6, 2026
Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
Published on: February 17, 2023
Lipid Profile Parameters under influence of Periodontitis Associated with Chronic Stress: An Animal Model Study
Alessandra Nogueira Porto1, Alvaro Henrique Borges, Alex Semenoff-Segundo
1Masters Program in Integrated Dental Sciences, University of Cuiaba Cuiaba, MT, Brazil.
Background:
The present study compared the effect of two chronic stress models associated with periodontitis induced in rats on partial lipid profile parameters.
Materials & Methods:
Forty-eight rats were divided into 4 groups: physical stress+periodontitis, variable stress+periodontitis, periodontitis and control. Physical stress and variable stress occurred over 60 days. After the first ten days of the stress test, periodontitis was induced by ligature. After 60 days of experimentation, the animals underwent incision and visualization of the posterior vena cava, and blood punctures were performed under a vacuum. Impartial and trained examiners performed the analysis of the parameters: low-density lipoprotein, high density lipoprotein, triglycerides and cholesterol.
Results:
The lipid parameters and cholesterol were significantly lower in the variable stress group than in the ligature and control groups. The physical stress group was not statistically different from the other groups. The triglyceride level was highest for the control group and statistically different from the levels in groups variable stress and physical stress. The physical stress group had the lowest triglyceride level, which was statistically different from that of the control group. There was no statistical difference between physical stress and variable stress with respect to low-density lipoprotein; a similar finding was obtained for ligature and control. The variable stress group had the lowest low-density lipoprotein level, which was statistically different from those of the ligature and control groups. High density lipoprotein levels showed no statistical differences between groups.
Conclusion:
Despite the limitations of the methodology, it seems that the stress model variable associated with periodontitis improved lipid parameters in the study. How to cite this article:Porto AN, Borges AH, Segundo AS, Semenoff TA, Pedro FL, Bandeca MC, Cortelli SC. Lipid profile parameters under influence of periodontitis associated with chronic stress: an animal model study. J Int Oral Health 2013; 5(4):8-14.
