Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

Modified-Release Drug Delivery Systems: Site-Targeted

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Advances and Future Challenges in Monolithic 3D Integrated Logic, Power, and Optoelectronics Technologies for Tightly Interconnected Intelligent Systems.

ACS nano·2026

Same author

HIPER-CHAD: Hybrid Integrated Prediction-Error Reconstruction-Based Anomaly Detection for Multivariate Indoor Environmental Time-Series Data.

Sensors (Basel, Switzerland)·2026

Same author

TiO<sub>2</sub>-Supported Ru-Fe Catalysts for the Hydrodeoxygenation of Bis(2-hydroxyethyl) Terephthalate (BHET) Prepared by the Glycolysis of Polyethylene Terephthalate (PET).

ChemSusChem·2025

Same author

Engineering of Corynebacterium glutamicum for para-coumaric acid biosynthesis from lignocellulosic biomass.

Bioresource technology·2025

Same author

Physicochemical and microbiological characteristics of pork meat exposed to SoRegen<sup>®</sup> Technology.

Veterinary world·2025

Same author

Corrigendum: Enhancing enzyme-mediated cellulose hydrolysis by incorporating acid groups onto the lignin during biomass pretreatment.

Frontiers in bioengineering and biotechnology·2025

Same journal

Emerging metallic nanotechnology platforms for cancer sensing and imaging.

Nano today·2026

Same journal

The landscape of nanomedical clinical trials.

Nano today·2026

Same journal

Nanofluidic delivery implant sustains localization and maximizes efficacy of intratumoral immunotherapy.

Nano today·2026

Same journal

Peroxidase-catalyzed proximity labeling to survey the proteome of nanomaterial-cell interface during macropinocytosis-mediated internalization.

Nano today·2025

Same journal

Efficient Intracellular Delivery of CRISPR-Cas9 Ribonucleoproteins Using Dendrimer Nanoparticles for Robust Genomic Editing.

Nano today·2025

Same journal

Lymph node targeting of cyclosporine ameliorates ocular manifestations in a mouse model of systemic lupus erythematosus (SLE) via PD-L1.

Nano today·2024

See all related articles

Search research articles

Related Experiment Video

Updated: May 6, 2026

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

Triggered Nanoparticles as Therapeutics.

Chang Soo Kim¹, Bradley Duncan, Brian Creran

¹Department of Chemistry, University of Massachusetts, Amherst, MA 01003 USA.

|October 26, 2013

Summary

This summary is machine-generated.

Engineered nanoparticles offer triggered drug release for improved drug delivery systems (DDSs). This review covers responsive nanomaterials for in vitro and in vivo applications, enhancing DDS efficacy.

Keywords:

Engineered nanoparticles drug delivery system in vitro in vivo triggered release

More Related Videos

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Published on: June 23, 2020

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Published on: October 10, 2025

Related Experiment Videos

Last Updated: May 6, 2026

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Published on: June 23, 2020

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Published on: October 10, 2025

Area of Science:

Biomedical Engineering
Materials Science
Nanotechnology

Background:

Drug delivery systems (DDSs) face challenges in site-specific delivery, stability, and controlled drug release.
Engineered nanoparticle (NP) surfaces with responsive moieties can improve DDS efficacy.
Triggered release mechanisms, using endogenous or exogenous stimuli, are key to overcoming DDS limitations.

Purpose of the Study:

To review recent advancements in triggered release strategies for engineered nanomaterials.
To highlight the application of these strategies in both in vitro and in vivo systems.
To discuss how responsive nanomaterials enhance the efficacy of drug delivery.

Main Methods:

Literature review of recent studies on triggered release from engineered nanomaterials.
Categorization of triggering mechanisms (endogenous and exogenous).
Analysis of applications in in vitro and in vivo settings.

Main Results:

Engineered nanomaterials with responsive surfaces show significant potential for DDS.
Both biological and external stimuli can effectively trigger drug release from nanoparticles.
These triggered release strategies enhance the performance of DDS in various experimental models.

Conclusions:

Triggered release from engineered nanomaterials is a promising approach to improve DDS.
Responsive NPs offer enhanced site-specific delivery, stability, and programmed release.
Further research in this area holds potential for advanced therapeutic applications.