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Updated: May 6, 2026

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa
Published on: September 27, 2018
Effect of electrical stimulation of the lower esophageal sphincter using endoscopically implanted temporary
Rupa Banerjee1, Nitesh Pratap, Rakesh Kalpala
1Asian Institute of Gastroenterology, 6-3-661, Somajiguda, Hyderabad, 500 082, India, dr_rupa_banerjee@hotmail.com.
Background:
Electrical stimulation therapy (EST) has been shown to increase lower esophageal sphincter (LES) pressure in animals; however, data on the effect of EST on LES pressure in patients with gastroesophageal reflux disease (GERD) are lacking.
Objective:
The aim of our study was to investigate the effect of EST on LES pressure and esophageal function in patients with GERD.
Methods:
Patients with a diagnosis of GERD responsive to proton pump inhibitors (PPIs), increased esophageal acid on 24-h pH monitoring off GERD medications, basal LES pressure >5 mmHg, hernia <2 cm and esophagitis
Results:
Six male patients (mean age 34.6 years) underwent successful endoscopic lead implantation; the first patient had premature lead dislodgement and did not undergo EST. The remaining five patients underwent successful EST. All patients had a significant increase in LES pressure with all sessions of EST. There was no effect on swallow-induced LES relaxation, And there were no EST-related adverse symptoms or any cardiac rhythm abnormalities.
Conclusions:
In patients with GERD, short-term EST delivered using electrodes endoscopically implanted in the LES results in a significant increase in LES pressure without affecting patients' swallow function or causing any adverse symptoms or cardiac rhythm disturbances. EST may offer a novel therapy to patients with GERD.
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