Related Experiment Video
Updated: May 6, 2026
11:44
Author Spotlight: Targeted Microinjection and Electroporation of Primate Cerebral Organoids for Genetic Modification
Published on: March 24, 2023
4.6K
Nonhuman primate models in the genomic era: a paradigm shift
ILAR Journal
|November 1, 2013
Summary
Harnessing genetic variation in nonhuman primates, like rhesus macaques, enhances biomedical research. Genomic data advances their use as human disease models, transforming study design and animal allocation.
Area of Science:
- Biomedical Research
- Genomics
- Primate Models
Background:
- Nonhuman primates are crucial biomedical research models due to human-like similarities.
- Substantial genetic variation in these primates can reduce statistical power and complicate study interpretations.
- Genomic advancements are poised to revolutionize their application in research.
Purpose of the Study:
- To explore the impact of genetic variation on nonhuman primate research.
- To highlight the transformative potential of genomic data in utilizing primate models.
- To discuss the paradigm shift in nonhuman primate research driven by genomics.
Main Methods:
- Analysis of genetic variation in nonhuman primate populations.
- Leveraging genomic data for improved study design.
- Investigating gene function and network intricacies in rhesus macaques.
Main Results:
- Genetic variation, while a challenge, offers opportunities for enhanced study design.
- Rhesus macaque gene function increasingly mimics human counterparts.
- Proliferation of genomic data is key to advancing primate research models.
Conclusions:
- Genomic data is essential for maximizing the utility of nonhuman primates in biomedical research.
- Integrating genetic insights transforms animal assignment and the development of human disease models.
- A new era of nonhuman primate research necessitates embracing genetic and genomic revolutions.
Related Concept Videos
02:31Synteny and Evolution
3.0K
John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
3.0K
02:02Genomics
35.6K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
35.6K
02:54Evolutionary Relationships through Genome Comparisons
5.9K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.9K
03:00Next-generation Sequencing
88.0K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
88.0K
02:46Genetic Screens
4.6K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
4.6K
02:43Mouse Models of Cancer Study
4.7K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
4.7K