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Updated: Aug 15, 2026

Overcoming Unresponsiveness in Experimental Autoimmune Encephalomyelitis (EAE) Resistant Mouse Strains by Adoptive Transfer and Antigenic Challenge
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Published on: April 9, 2012

T lymphocyte clones and experimental autoimmune diseases

I R Cohen

    Behring Institute Mitteilungen
    |August 1, 1985
    PubMed

    This article reviews some of the lessons derived from our use of T lymphocyte lines and clones to study three experimental autoimmune diseases: experimental autoimmune encephalomyelitis, experimental autoimmune thyroiditis and adjuvant arthritis. In each of these disease models we have raised lines and clones of T lymphocytes of the helper phenotype that are specifically autoimmune. These T lymphocytes were used to investigate the pathogenesis of disease. Lines and clones were also exploited to induce resistance to disease.

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