Related Experiment Video
Updated: May 6, 2026
07:35
Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
10.9K
[Renal cancer and hereditary diseases]
1Aix-Marseille université, 27, boulevard Jean-Moulin, 13284 Marseille, France; Service d'urologie et transplantation rénale, hôpital La Conception, AP-HM, 13385 Marseille, France.
Summary
Hereditary diseases can cause rare renal tumors with varied symptoms. Early detection and genetic counseling are key for managing these complex cases and ensuring conservative treatment.
Area of Science:
- Nephrology
- Oncology
- Genetics
Context:
- Renal tumors linked to hereditary conditions are uncommon.
- These tumors often present with multiple renal lesions and systemic manifestations (pulmonary, neurological, dermatological).
Purpose:
- To highlight the importance of recognizing hereditary patterns in renal tumors.
- To emphasize the need for multidisciplinary management involving surgical specialties and geneticists.
Summary:
- Hereditary renal tumors are rare, multifocal, and often bilateral, suggesting a genetic predisposition.
- Clinical presentation includes diverse systemic symptoms alongside kidney tumors.
- Management necessitates a collaborative approach between surgeons and geneticists for optimal outcomes.
Impact:
- Facilitates earlier diagnosis of hereditary cancer syndromes.
- Promotes timely genetic screening and counseling for at-risk individuals.
- Enables personalized, conservative treatment strategies and improved patient surveillance.
More Related Videos
Related Concept Videos
02:59Cancer Prevention
6.5K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.5K
01:20The Retinoblastoma Gene
2.2K
2.2K
01:20The Retinoblastoma Gene
3.7K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
3.7K
01:25Chronic Kidney Disease I: Introduction
1.4K
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
1.4K
01:28Chronic Kidney Disease III: Interprofessional Care
706
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
706
01:28Diabetic Nephropathy
52
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration...
52