Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

6.4K
A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
6.4K
Types of Fever01:25

Types of Fever

1.7K
Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
1.7K
Stages of Infection01:26

Stages of Infection

70.4K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
70.4K
Patterns of Fever01:26

Patterns of Fever

4.8K
Before understanding the types and patterns of fever, it is essential to know its phases.
4.8K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

14.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.1K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

3.8K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Violaceous Lesion and Pulmonary Necrosis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025
Same author

The Pink Road Less Traveled.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025
Same author

Corrigendum to "Discoidin domain receptor 1 activation links extracellular matrix to podocyte lipotoxicity in Alport syndrome" eBioMedicine, Volume 63, January 2021, 103162.

EBioMedicine·2025
Same author

Effect of Differentiated Service Delivery Model on Retention to Care among People Living with HIV in Rwanda: A Retrospective Cohort Analysis.

Rwanda journal of medicine and health sciences·2025
Same author

Factors Associated With Recent HIV Infections Among Newly HIV Diagnosed in Rwanda.

Journal of acquired immune deficiency syndromes (1999)·2025
Same author

Differences in Trends in Cancer Incidence Rates Among People With HIV During 2001-2019 by Race and Ethnicity and by Risk Group in the United States.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2024
Same journal

Why Dispelling Myths and Misconceptions in Emergency Medicine Matters.

Emergency medicine clinics of North America·2026
Same journal

Myths and Misconceptions in Emergency Medicine.

Emergency medicine clinics of North America·2026
Same journal

Acute Otitis Media-Watch and Wait Is Not a Myth.

Emergency medicine clinics of North America·2026
Same journal

Hot or Not? Myths and Misconceptions About Antipyretics for Pediatric Fever.

Emergency medicine clinics of North America·2026
Same journal

Epinephrine Improves Outcomes in Out-Of-Hospital Cardiac Arrests.

Emergency medicine clinics of North America·2026
Same journal

Myth: Pretreatment Prevents Intravenous Contrast Reactions in the Emergency Department.

Emergency medicine clinics of North America·2026
See all related articles

Related Experiment Video

Updated: May 6, 2026

Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses
10:10

Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses

Published on: November 16, 2016

12.5K

Fever in immunocompromised hosts.

Devang M Patel1, David J Riedel

  • 1Division of Infectious Disease, Department of Medicine, Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA.

Emergency Medicine Clinics of North America
|November 2, 2013
PubMed
Summary
This summary is machine-generated.

Fever in immunocompromised patients requires prompt diagnosis and management due to potentially life-threatening infections. This review covers fever causes and treatment in patients with HIV/AIDS, transplants, neutropenia, and TNF-α inhibitor use.

Keywords:
AIDSEmergency departmentFeverHIVHematopoietic stem cell transplantNeutropenic feverSolid-organ transplantTumor necrosis factor-α inhibitors

More Related Videos

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.5K
Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
08:44

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

2.3K

Related Experiment Videos

Last Updated: May 6, 2026

Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses
10:10

Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses

Published on: November 16, 2016

12.5K
Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.5K
Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
08:44

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

2.3K

Area of Science:

  • Infectious Diseases
  • Immunology
  • Oncology

Background:

  • Fever is a common emergency department presentation for immunocompromised patients.
  • The differential diagnosis for fever in this population is broad, including rare pathogens.
  • Untreated infections can lead to rapid deterioration and death.

Purpose of the Study:

  • To review the diagnosis and management of fever in immunocompromised patients.
  • To highlight critical considerations for specific immunosuppression types.

Main Methods:

  • Literature review focusing on fever in immunocompromised states.
  • Synthesis of diagnostic and management strategies.

Main Results:

  • Identified key patient groups: HIV/AIDS, solid-organ and hematopoietic transplants, chemotherapy-induced neutropenia, and TNF-α inhibitor users.
  • Emphasized the need for prompt recognition of immunosuppression type and fever etiology.

Conclusions:

  • Effective management hinges on rapid identification of the immunosuppressive condition and potential infectious agents.
  • Timely intervention is crucial for improving outcomes in febrile immunocompromised patients.