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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Acquired factor VIII deficiency presenting with compartment syndrome
Thuy V Pham1, Carina A Sorenson2, Jose V Nable3
1Department of Emergency Medicine, University of Maryland Medical Center, Baltimore, MD.
The American Journal of Emergency Medicine
|November 2, 2013
Summary
Acquired factor VIII deficiency, a rare bleeding disorder, can be life-threatening. Prompt recognition in emergency settings is crucial to prevent severe complications, especially during surgery.
Area of Science:
- Hematology
- Emergency Medicine
Background:
- Acquired factor VIII deficiency is a rare but serious bleeding disorder.
- Its rarity can delay diagnosis despite classic symptoms.
Observation:
- An elderly woman presented with spontaneous bilateral lower extremity compartment syndrome.
- Initial presentation included tachycardia, hypotension, anemia, and elevated activated partial thromboplastin time.
Findings:
- The patient underwent bilateral fasciotomies with postoperative incisional bleeding.
- Acquired factor VIII deficiency was diagnosed postoperatively.
Implications:
- Emergency physicians must be aware of acquired factor VIII deficiency for timely diagnosis.
- Early identification can prevent severe complications, particularly in patients undergoing surgery.
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