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Published on: February 24, 2023
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Stratified medicine for mental disorders.
Gunter Schumann1, Elisabeth B Binder2, Arne Holte3
1MRC-Social Genetic Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, PO80, 16 De Crespigny Park, London SE5 8AF, UK.
Summary
Novel biomedical research approaches are advancing mental disorder understanding and treatment. A new strategy, supported by the Roadmap for Mental Health Research (ROAMER), aims to integrate research for better public health outcomes.
Area of Science:
- Biomedical research
- Neuroscience
- Mental health science
Background:
- Biomedical research into mental disorders requires novel approaches.
- Advances in understanding brain development and environmental influences are key.
- Stratified medicine offers targeted treatments by addressing etiological mechanisms.
Purpose of the Study:
- To provide recommendations for a European mental health research strategy.
- To integrate biomedical, psychological, and public health research.
- To address the public health burden and individual suffering from mental disorders.
Main Methods:
- Assessment of the state of the art in core psychopathological domains.
- Identification of major advances, promising methods, and research gaps.
- Integration of expertise from leading experts in biomedical research on mental disorders.
Main Results:
- Progress in understanding arousal/stress regulation, affect, cognition, social processes, comorbidity, and pharmacotherapy.
- Identification of key areas for future research to advance stratified medicine.
- Recognition of the need for a cohesive European mental health research strategy.
Conclusions:
- Stratified medicine holds promise for more precise diagnostics and targeted treatments for mental disorders.
- A comprehensive research strategy is needed to harness advances in biomedicine and related fields.
- The Roadmap for Mental Health Research (ROAMER) initiative supports the development of this strategy.
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