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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

3.8K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.1K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

65.0K
Overview
65.0K
Humoral Immune Responses01:36

Humoral Immune Responses

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Overview
66.4K
Development of Immunocompetence01:22

Development of Immunocompetence

1.2K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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Updated: May 6, 2026

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR
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Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR

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Patients with immunodeficiency.

Michael J Hannaman1, Melissa J Ertl

  • 1Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, B6/319 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792-3272, USA.

The Medical Clinics of North America
|November 5, 2013
PubMed
Summary
This summary is machine-generated.

Patients with compromised immune systems require careful surgical evaluation due to potential multiorgan dysfunction from conditions like HIV, cancer, or transplantation. Understanding these risks is key to optimizing surgical outcomes.

Keywords:
CancerHuman immunodeficiency virusImmunocompromisedPreoperativeTransplant

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Area of Science:

  • Immunology
  • Surgical Oncology
  • Transplantation Medicine

Background:

  • Immunocompromised patients present unique challenges for surgical fitness assessment.
  • Conditions such as human immunodeficiency virus (HIV), cancer, and organ transplantation significantly impact immune function.
  • These conditions and their treatments can lead to systemic effects and multiorgan dysfunction.

Purpose of the Study:

  • To highlight the critical need for specialized evaluation of immunocompromised patients undergoing surgery.
  • To emphasize the importance of understanding the perioperative implications of immunodeficiency.

Main Methods:

  • Review of literature on immunocompromised states and surgical risk.
  • Analysis of systemic effects of immunodeficient conditions and therapies.
  • Discussion of perioperative management strategies.

Main Results:

  • Immunocompromised states, including HIV, cancer, and transplantation, necessitate thorough preoperative assessment.
  • Potential for multiorgan dysfunction is a significant concern in this patient population.
  • Multifaceted systemic effects require careful consideration.

Conclusions:

  • Optimal perioperative outcomes for immunocompromised surgical patients depend on a comprehensive understanding of their condition.
  • Specialized evaluation protocols are essential for this patient group.
  • Proactive management of disease manifestations is crucial for surgical success.