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[Lymphatics and lung transplantation. A review]
F Le Pimpec-Barthes1, P Mordant1, C Pricopi1
1Service de chirurgie thoracique, oncologique et générale, transplantation pulmonaire, faculté Paris Descartes, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris cedex 15, France.
Revue De Pneumologie Clinique
|November 5, 2013
Summary
Investigating lymph circulation in lung transplantation (LTx) is crucial for understanding unpredictable graft edema and primary graft failure. Animal models highlight the impact of lymphatic vessel interruption and regeneration on LTx outcomes.
Area of Science:
- Transplantation immunology
- Vascular biology
- Surgical research
Context:
- Post-lung transplant (LTx) edema is unpredictable and unexplained, contributing to primary graft failure.
- Animal models, particularly in small bowel transplantation, offer insights into lymphatic vessel function and regeneration relevant to LTx.
Purpose:
- To review existing studies on lymphatic vessel interruption, regeneration, and their role in immune responses after lung transplantation (LTx).
- To explore the potential link between altered lymph circulation and post-LTx edema and primary graft failure.
Summary:
- Studies in animal models highlight lymphatic vessel interruption and regeneration consequences after transplantation.
- Lymphatic vessels play a role in rejection induction, local immune response, and obliterative bronchiolitis following LTx.
Impact:
- Understanding lymphatic circulation's role can elucidate causes of primary graft failure in lung transplantation (LTx).
- This review provides a foundation for future research into optimizing lung transplant outcomes by addressing lymphatic dysfunction.
