Future of biosensors: a personal view

Area of Science:

• Biotechnology
• Nanotechnology
• Analytical Chemistry

Background:

• Biosensors, analogous to living senses, are established in glucose monitoring and drug development.
• Current biosensor technologies are advanced but require further innovation for broader applications.
• The development of affordable personal genome sequencing relies on overcoming challenges in nanopore and single-molecule sequencing.

Purpose of the Study:

• To explore advancements in biosensor technology, including novel recognition elements and nanomaterial integration.
• To discuss the potential of molecularly imprinted polymers (MIPs) as stable alternatives to biological recognition elements.
• To highlight the future integration of biosensors for personalized medicine and decentralized monitoring.

Main Methods:

• Cell-free protein synthesis for tailor-made recognition elements.
• Chemical synthesis of molecularly imprinted polymers (MIPs) as antibody alternatives.
• Integration of nanomaterials, such as graphene, for enhanced biosensor performance.

Main Results:

• MIPs show potential to replace antibodies in biosensors for detecting various analytes, offering greater stability and scalability.
• Nanomaterial integration, particularly graphene, promises miniaturized biosensors with high sensitivity and rapid response times.
• Enzyme electrodes are valuable for pharmacogenetic profiling and pharmacokinetic analysis.

Conclusions:

• Biosensor technology is advancing towards personalized medicine through genetic profiling and tailored therapies.
• The development of "autonomous" biosensors will enable decentralized, real-time monitoring in diverse environments and consumer products.
• Molecularly imprinted polymers and nanomaterials are key innovations driving the next generation of biosensors.