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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Determinants of severity at presentation among young patients with early onset glaucoma

Viney Gupta1, Rajat M Srivastava, Ramanjit Sihota

  • 1Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Indian Journal of Ophthalmology
|November 12, 2013
PubMed

Insights

Juvenile primary open angle glaucoma (JOAG) patients with lower socio-economic status and higher intraocular pressure (IOP) present with more severe disease. A family history is linked to earlier presentation and reduced severity.

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Public Health

Background:

  • Juvenile primary open angle glaucoma (JOAG) is a severe form of glaucoma.
  • Understanding factors influencing disease severity at presentation is crucial for early intervention.

Purpose of the Study:

  • To identify clinical, socio-economic, and demographic factors associated with JOAG severity at presentation.
  • To analyze the impact of family history, intraocular pressure (IOP), and socio-economic status on disease severity.

Main Methods:

  • Retrospective analysis of 80 unrelated JOAG patients (age 10-40).
  • Factors analyzed include age at diagnosis, family history, baseline IOP, healthcare access, socio-economic status, and glaucoma awareness.
  • Severity graded using the Advanced Glaucoma Intervention Study (AGIS) score and binocular visual field defects.

Main Results:

  • Lower socio-economic status (OR 5.7) and higher baseline IOP (OR 7) were significantly associated with severe visual field defects.
  • A positive family history correlated with earlier presentation (4 years earlier).
  • Conversely, a negative family history was linked to a 10-fold increased likelihood of severe presentation (OR 0.1).

Conclusions:

  • Clinical, socio-economic, and demographic factors significantly influence the severity of JOAG at presentation.
  • Family history is a key factor, associated with earlier diagnosis and a lower risk of severe disease.
  • Socio-economic status and baseline IOP are critical indicators of disease severity in young glaucoma patients.
Abstract

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