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Auditory event-related signals in mouse ERG recordings
Naoyuki Tanimoto1, Vithiyanjali Sothilingam, Gabriele Gloeckner
1Division of Ocular Neurodegeneration, Institute for Ophthalmic Research, Centre for Ophthalmology, Eberhard Karls University, Schleichstr. 4/3, 72076, Tübingen, Germany, naoyuki.tanimoto@med.uni-tuebingen.de.
Documenta Ophthalmologica. Advances in Ophthalmology
|November 14, 2013
Summary
The sound of a flash, not the light itself, can create an electrical signal in mouse electroretinogram (ERG) recordings. This auditory artifact is significant when visual responses are minimal.
Area of Science:
- Neuroscience
- Ophthalmology
- Auditory Science
Background:
- Electroretinogram (ERG) recordings in mice sometimes show unexpected electrical signals.
- These signals appear when retinal electrical activity is low and do not correlate with stimulus intensity.
Purpose of the Study:
- To investigate the origin of a specific event-related component observed in mouse ERG recordings.
- To determine if this component is related to the light flash or the sound it produces.
Main Methods:
- Utilized Xenon flash ERG systems on various mouse models, including wild-type, photoreceptor-deficient, and deaf mice.
- Employed an acoustic noise generator to mask the sound of the flash discharge.
Main Results:
- An event-related signal (a-wave and b-wave like deflections) was detected in conditions with minimal visual response.
- This signal was absent in deaf mice (Cdh23 (vAlb/vAlb)) and disappeared when the flash discharge sound was masked.
- The signal was reversible upon removal of acoustic masking.
Conclusions:
- Identified an auditory event-related component, likely resembling auditory evoked potentials, as a source of non-visual ERG signals in mice.
- This finding is crucial for accurate interpretation of ERG data, especially in mice with diminished visual function.
