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Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases

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Published on: January 1, 2016

Rapid kill-novel endodontic sealer and Enterococcus faecalis.

Nurit Beyth¹, Dana Kesler Shvero, Nathan Zaltsman

¹Department of Prosthodontics, Faculty of Dentistry, The Hebrew University-Hadassah, Jerusalem, Israel.

|November 14, 2013

Summary

This study introduces a novel endodontic sealer with nanoparticles that effectively kills Enterococcus faecalis, a common cause of endodontic failure. The sealer demonstrates potent antimicrobial activity while remaining safe and maintaining physical integrity.

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Area of Science:

Endodontics
Microbiology
Materials Science

Background:

Bacterial resistance necessitates novel antimicrobial strategies, particularly for endodontic treatment failures caused by oral microorganisms.
Quaternary ammonium compounds show promise against resistant bacteria due to their surface interaction mechanism.

Purpose of the Study:

To investigate the efficacy and safety of a novel endodontic sealer incorporating nano-sized quaternary ammonium particles.
To evaluate the sealer's potential to limit Enterococcus faecalis growth and overcome bacterial resistance.

Main Methods:

Synthesis of nano-sized quaternary amine particles using a polyethyleneimine scaffold.
Incorporation of nanoparticles into an epoxy-based endodontic sealer.
Testing of the sealer for antimicrobial efficacy, biocompatibility, and physical properties.

Main Results:

The novel sealer effectively limits Enterococcus faecalis growth by utilizing surface bactericidal properties of nanoparticles.
Nanoparticle penetration into eukaryotic cells was impeded, mitigating potential toxicity.
The sealer maintained adequate physical properties for endodontic applications.
Nanosized quaternary amine particles demonstrated rapid interaction with bacteria, causing cell death across a range of pH values.

Conclusions:

A novel, safe, and effective antibacterial endodontic sealer was developed.
This represents a new approach to combating bacterial infections in endodontics.
The sealer offers a promising solution against resistant bacterial strains in endodontic treatments.