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Split Hybridization Probe Utilizing a DNA Fluorescent Light-up Aptamer as a Signal Reporter for Sequence-Specific Nucleic Acid Analysis
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A new type of DNA "light-switch": a dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA
Erin Wachter1, Brock S Howerton, Emily C Hall
1Department of Chemistry, University of Kentucky, Lexington KY 40506, USA. ec.glazer@uky.edu.
Abstract:
Ru(bpy)2dppz, a well studied "light-switch" metal complex, transforms into a photochemical "light-switch" and DNA damaging agent by incorporating structural strain. This distorted compound is photoreactive and ejects a ligand upon binding duplex and G-quadruplex DNA, producing a reactive metal center that metalates the DNA.

