[Effectiveness of therapy of endometriosis with danazol and chlormadinone acetate and their effect on paraclinical...

The effect of danazol in a dose of 400 mg-800 mg per day for 6 month was studied in 10 women and also chlormadinone acetate 2 X 2 mg per day. Clinical investigation and laboratory test were done before the therapy has been started, during treatment (after the 2 and the 6 month) and 2 month after the end of therapy. Two month after discontinuation of danazol 5 women were free of symptoms. The metabolic studies revealed significant changes in many biochemical parameters. Two month after discontinuation of chlormadinone acetate also 5 women were free of symptoms. The metabolic studies revealed significant changes only for the blood plateled concentration and serum bilirubin.