Related Experiment Video
Updated: May 5, 2026
09:39
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
9.2K
Cyclodextrin-based nanocomplexes for sustained delivery of human growth hormone
Maharajan Sivasubramanian1, Joon-Youl Lee, Kap Jin Kim
1Department of Advanced Polymer and Fiber Materials, Kyung Hee University, Gyeonggi-do 446-701, Republic of Korea.
Journal of Nanoscience and Nanotechnology
|November 20, 2013
Summary
Glycol chitosan-beta-cyclodextrin nanoparticles offer a novel solution for delivering human growth hormone (hGH). These nanoparticles provide sustained release of hGH for up to 9 days, overcoming its instability and short half-life.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Nanotechnology
Background:
- Therapeutic use of human growth hormone (hGH) is constrained by its instability and short in vivo half-life.
- Developing effective delivery systems is crucial for improving hGH efficacy.
Purpose of the Study:
- To synthesize and characterize a novel glycol chitosan-beta-cyclodextrin (GC-betaCD) conjugate for sustained hGH delivery.
- To evaluate the encapsulation efficiency and in vitro release profile of hGH from GC-betaCD nanoparticles.
Main Methods:
- GC-betaCD conjugate synthesized via covalent attachment of carboxymethyl betaCD to glycol chitosan backbone.
- Self-assembled nanoparticles formed through hydrogen bonding among betaCD units.
- hGH encapsulation achieved via hydrophobic interactions within betaCD cavities.
- In vitro release studies conducted over 9 days.
Main Results:
- GC-betaCD conjugate formed stable nanoparticles with a mean diameter of 340 nm.
- Effective encapsulation of hGH into nanoparticles demonstrated.
- Sustained in vitro release of hGH observed over a 9-day period.
Conclusions:
- The synthesized GC-betaCD conjugate shows potential as a carrier for sustained hGH delivery.
- This approach may overcome limitations associated with conventional hGH administration.
- Further research is warranted to explore in vivo applications.
Related Concept Videos
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
165
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
165
01:26Oral Drug Delivery Systems: Continuous-Release Systems
319
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
319
01:24Modified-Release Drug Delivery Systems: Site-Targeted
167
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
167
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
336
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
336
01:19Modified-Release Drug Delivery Systems: Rate-Programmed II
139
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
139
01:30Modified-Release Drug Delivery Systems: Stimuli-Activated
184
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
184