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Updated: May 5, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Spontaneous resolution of lupus nephritis following withdrawal of etanercept
Taher M Yahya1, Susmitha Dhanyamraju, Thomas M Harrington
1Geisinger Medical Center, Suite 13-48, 100 N Academy Ave, Danville, PA 17822, USA; e mail: tmyahya@geisinger.edu.
Introduction:
Etanercept, a systemic inhibitor of α-TNF, is used for treatment of various autoimmune disorders. We report a case of spontaneous resolution of etanercept-induced lupus nephritis.
Case Description:
A 57-year-old female patient taking etanercept for psoriasis presented with laboratory-and histology-confirmed lupus nephritis. After stopping etanercept, there was normalization of proteinuria, hematuria, serum complements, anti-dsDNA antibody, and resolution of the acute glomerular inflammatory process on repeat kidney biopsy.
Conclusion:
This case demonstrates serology- and biopsy-confirmed resolution of active lupus nephritis upon withdrawal of etanercept.
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