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Lomotil (diphenoxylate) dependence in India
Aseem Mehra1, Siddharth Sarkar, Debasish Basu
1Department of Psychiatry, Level 3, Cobalt Block, Nehru Hospital, PGIMER, Chandigarh, India.
Indian Journal of Psychological Medicine
|November 20, 2013
Summary
Lomotil (diphenoxylate-atropine) abuse is a growing concern, with 41 patients presenting with dependence. This study highlights the need for regulatory controls on this easily accessible prescription drug.
Area of Science:
- Pharmacology
- Addiction Medicine
- Public Health
Background:
- Lomotil (diphenoxylate-atropine) is an antidiarrheal agent with abuse potential due to its opioid component.
- Published reports on Lomotil abuse are limited, necessitating further investigation into its characteristics.
Purpose of the Study:
- To evaluate the characteristics of patients dependent on Lomotil presenting to a treatment center.
- To understand the patterns and reasons for Lomotil abuse.
Main Methods:
- Retrospective chart review of patients presenting with Lomotil dependence.
- Data collected from a Drug De-addiction and Treatment Centre in India over five years.
Main Results:
- Identified 41 patients with Lomotil dependence as the primary substance of abuse.
- Typical users were married, employed males, educated to 10th grade, from rural Sikh families.
- Daily intake ranged from 3-250 tablets (median 25); initiation reasons included withdrawal relief, cheap opioid substitute, curiosity, and peer suggestion.
Conclusions:
- Lomotil exhibits significant abuse potential, requiring regulatory controls.
- Easily available prescription drugs like Lomotil can escalate misuse without proper oversight.
- Findings underscore the need for stricter regulations to prevent widespread abuse of diphenoxylate-containing medications.
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