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The Mammary Glands01:12

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The female breast is a hemispheric projection of variable size positioned anterior to the pectoralis major and serratus anterior muscles. A fascia layer composed of dense, irregular connective tissue connects it to these muscles.
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Related Experiment Video

Updated: May 5, 2026

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
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Bilateral breast in brothers - abreast.

Altamash Mohammed Yusuf Shaikh1, Sameer Yadav, Nivedita D Moulick

  • 1Department of Medicine And Endocrine Services, Lokmanya Tilak Municipal General Hospital, Mumbai, Maharashtra, India.

Indian Journal of Endocrinology and Metabolism
|November 20, 2013
PubMed
Summary

Gynecomastia is common in puberty, often physiological. This case study highlights two brothers with distinct causes of gynecomastia, emphasizing the need for thorough investigation within families to identify treatable conditions.

Keywords:
BilateralKlinefelterbreastfamilialgynecomastiaphysiological

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Area of Science:

  • Endocrinology
  • Pediatrics
  • Genetics

Background:

  • Gynecomastia is a frequent condition in adolescents, with physiological causes in up to 65% of cases.
  • Familial occurrence warrants investigation to rule out underlying treatable etiologies.
  • Early diagnosis and management are crucial for patient well-being.

Observation:

  • Two brothers presented with bilateral gynecomastia.
  • The brothers exhibited different underlying causes for their gynecomastia.
  • Distinct treatment approaches were required for each brother.

Findings:

  • This case series underscores the importance of a comprehensive etiological workup for gynecomastia, even within the same family.
  • Identified distinct pathologies necessitating tailored therapeutic strategies.
  • Highlighted the potential for varied presentations and management needs in familial gynecomastia.

Implications:

  • Emphasizes the need for individualized diagnostic and treatment plans for gynecomastia.
  • Suggests genetic or environmental factors may contribute to varied presentations in familial cases.
  • Informs clinical practice regarding the thorough investigation of adolescent gynecomastia within family contexts.