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AIDS encephalopathy.

R W Price, B A Navia, E S Cho

    Neurologic Clinics
    |February 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Acquired immunodeficiency syndrome (AIDS) often involves brain damage, leading to dementia and motor problems. Research suggests this neurological complication may stem from direct infection by the human immunodeficiency virus (HIV).

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    Area of Science:

    • Neurology
    • Infectious Diseases
    • Virology

    Background:

    • Acquired immunodeficiency syndrome (AIDS) is frequently complicated by a progressive encephalopathy.
    • This neurological disorder is characterized by dementia and motor dysfunction.

    Purpose of the Study:

    • To review the clinical features of AIDS-related encephalopathy.
    • To examine evidence for direct brain infection by the retrovirus causing AIDS.

    Main Methods:

    • Literature review of early and late clinical features.
    • Analysis of current evidence regarding direct retroviral brain infection.

    Main Results:

    • AIDS encephalopathy presents with progressive dementia and motor deficits.
  • Evidence supports direct brain infection by the causative retrovirus as a cause.

    • Conclusions:

    • AIDS-related encephalopathy is a significant neurological complication.
    • Direct retroviral brain infection is a likely cause of this disorder.