[A case of retroperitoneal angiosarcoma effectively treated with recombinant interleukin-2]

Area of Science:

• Oncology
• Vascular Neoplasms
• Immunotherapy

Background:

• Angiosarcoma is a rare, highly malignant vascular neoplasm.
• Primary retroperitoneal angiosarcoma is exceptionally rare, posing diagnostic challenges due to non-specific imaging features.
• Effective treatments for retroperitoneal angiosarcoma remain to be established.

Observation:

• A 60-year-old woman presented with abdominal pain and a retroperitoneal mass, initially misdiagnosed as a chronic expanding hematoma.
• Histopathological diagnosis confirmed primary retroperitoneal angiosarcoma.
• Local recurrence was detected one month post-surgery via FDG-PET.

Findings:

• Salvage immunotherapy using recombinant interleukin-2 (rIL-2) was initiated for local recurrence.
• The patient achieved a complete response to rIL-2 therapy.
• The patient remains well 19 months post-surgery and immunotherapy.

Implications:

• This case highlights the potential of rIL-2 as a salvage immunotherapy for recurrent retroperitoneal angiosarcoma.
• Prompt diagnosis and multimodal treatment strategies are crucial for managing this rare malignancy.
• Further research into immunotherapy for angiosarcoma is warranted.