IL10 polymorphisms associated with Behçet's disease in Chinese Han

Area of Science:

• Genetics
• Immunology
• Rheumatology

Background:

• Interleukin-10 (IL-10) is a key anti-inflammatory cytokine implicated in Behçet's disease (BD) pathogenesis.
• Previous genome-wide association studies suggest the IL10 gene as a potential BD risk factor.

Purpose of the Study:

• To investigate the association between IL10 gene polymorphisms and Behçet's disease (BD) in the Chinese Han population.

Main Methods:

• Genotyping of 407 BD patients and 679 healthy controls using the Sequenom MassArray system.
• Analysis of single nucleotide polymorphisms (SNPs) including rs1800871, rs1518111, rs3021094, and rs3790622.
• Haplotype analysis and meta-analysis incorporating existing data.

Main Results:

• The risk allele of rs1800871 was significantly more frequent in BD patients (71.9%) compared to controls (66.2%) (pc=0.024).
• SNPs rs1518111 and rs3021094 also showed significant associations with BD (pc=0.026 and pc=0.035, respectively).
• A specific haplotype (GACC) and meta-analysis results further supported the association of rs1800871 and rs1518111 with BD.

Conclusions:

• IL10 gene polymorphisms are associated with Behçet's disease susceptibility in the Chinese Han population.
• The findings indicate that IL10 may function as a susceptibility gene for BD in this demographic.