Clinical pharmacology in old persons
Paul A F Jansen1, Jacobus R B J Brouwers
1Expertise Centre Pharmacotherapy in Old Persons, University Medical Centre Utrecht, B05.256, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.
The global population is aging rapidly, posing public health challenges. This paper outlines key principles of geriatric pharmacology to ensure safe and effective medication use in older adults with multiple health conditions.
Area of Science:
- Geriatric Medicine
- Pharmacology
- Public Health
Background:
- The global population is experiencing a significant epidemiological transition, with a projected increase in individuals over 65 years old from 11% in 2010 to 32% by 2100.
- Older adults frequently present with multiple comorbidities, necessitating complex medication regimens.
- Age-related changes in pharmacokinetics and pharmacodynamics, alongside challenges in drug access and adherence, complicate pharmacotherapy in the elderly.
Purpose of the Study:
- To present the fundamental principles of geriatric pharmacology.
- To address the challenges of safe and effective pharmacotherapy in an aging global population.
Main Methods:
- Review of current literature on geriatric pharmacology.
- Synthesis of established principles for medication management in older adults.
Main Results:
- Discussion of age-related alterations in drug absorption, distribution, metabolism, and excretion.
- Highlighting common challenges in medication adherence and persistence among elderly patients.
- Identification of strategies for optimizing pharmacotherapy in geriatric patients.
Conclusions:
- Safe and effective pharmacotherapy is a critical challenge in geriatric medicine.
- Understanding geriatric pharmacology principles is essential for improving health outcomes in the aging population.
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