Bone Formation in a Local Defect around Dental Implants Coated with Extracellular Matrix Components
Raquel R M de Barros1, Arthur B Novaes1, Paula Korn2
1University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Clinical Implant Dentistry and Related Research
|November 29, 2013
Summary
Coating dental implants with collagen/chondroitin sulfate (collagen/CS) enhanced bone healing in peri-implant defects. While larger gaps hindered bone formation, the collagen/CS coating improved bone volume near the implant surface.
Area of Science:
- Biomaterials Science
- Dental Implantology
- Tissue Engineering
Background:
- Peri-implant bone healing is crucial for dental implant success.
- Extracellular matrix components can modulate bone regeneration.
- Understanding surface modifications' impact on healing is vital.
Purpose of the Study:
- To evaluate the effect of collagen/chondroitin sulfate (collagen/CS) coated implant surfaces on peri-implant bone healing.
- To analyze bone formation in a canine mandibular defect model with varying gap sizes.
Main Methods:
- 48 sandblasted and acid-etched implants were placed in dog mandibles.
- Some implants were additionally coated with collagen/CS.
- Peri-implant defects of 0.5, 1.0, and 2.0 mm widths were created.
- Histology, histomorphometry, and fluorochrome staining assessed osseointegration.
Main Results:
- Increased mineralization was observed around collagen/CS coated surfaces at 4 weeks.
- Bone apposition decreased with increasing gap size for both implant types.
- Collagen/CS coated implants showed greater bone volume in gapless and 0.5 mm gaps compared to uncoated implants.
Conclusions:
- Peri-implant gap width significantly influences bone formation.
- Complete gap filling was not achieved with either surface type.
- Collagen/CS coating positively affected bone formation in close proximity to the implant surface.
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