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Complications of diabetes therapy

Sarah D Corathers1, Shawn Peavie, Marzieh Salehi

  • 1Division of Endocrinology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7012, Cincinnati, OH 45229, USA; Division of Endocrinology, University of Cincinnati Medical Center, 260 Stetson, Suite 4200, Cincinnati, OH 45229, USA.

Endocrinology and Metabolism Clinics of North America
|November 30, 2013
PubMed

Insights

Managing type 2 diabetes requires individualized plans to control glucose and minimize risks. This review details non-insulin medication complications, focusing on side effects and effects on beta-cell function.

Area of Science:

  • Endocrinology
  • Pharmacology

Background:

  • Type 2 diabetes mellitus (T2DM) management focuses on individualized glycemic control.
  • Progressive beta-cell dysfunction presents a significant challenge to long-term glycemic control.
  • Minimizing treatment-related risks is a key aspect of current T2DM strategies.

Purpose of the Study:

  • To identify and review complications associated with non-insulin treatments for T2DM.
  • To provide a comprehensive overview of major non-insulin medication classes.
  • To highlight effects on beta-cell function and other class-specific side effects.

Main Methods:

  • Review of major classes of non-insulin antidiabetic medications.
  • Focus on target populations, mechanisms of action, and weight effects.
  • Analysis of cardiovascular outcomes and additional class-specific side effects, including bone effects.

Main Results:

  • Non-insulin T2DM treatments present various complications and side effects.
  • Medication classes differ in their impact on weight, cardiovascular health, and bone.
  • Effects on beta-cell function vary among different treatment classes.

Conclusions:

  • Understanding non-insulin treatment complications is crucial for individualized T2DM care.
  • Class-specific side effects, including impact on bone and cardiovascular outcomes, require careful consideration.
  • The progressive nature of T2DM necessitates ongoing evaluation of treatment efficacy and safety, including effects on beta-cell reserve.
Keywords:
Cardiovascular outcomesDiabetesTreatment complicationsβ-cell function

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