Nickel oxide hollow microsphere for non-enzyme glucose detection

Area of Science:

• Materials Science
• Electrochemistry
• Nanotechnology

Background:

• Development of efficient and stable electrocatalysts for glucose oxidation is crucial for biosensor applications.
• Hollow microsphere structures offer high surface area and enhanced electrochemical properties.

Purpose of the Study:

• To develop a facile synthesis strategy for nickel oxide hollow microspheres (NiO-HMSs).
• To investigate the electrochemical performance of NiO-HMSs for the electrocatalytic oxidation of glucose.
• To evaluate the potential of NiO-HMSs in enzyme-free amperometric glucose sensing.

Main Methods:

• Solvothermal synthesis using a mixed solvent of ethanol and water with sodium dodecyl sulfate (SDS).
• Characterization using transmission electron microscopy (TEM), scanning electron microscopy (SEM), and powder X-ray diffraction (XRD).
• Electrochemical studies including cyclic voltammetry and amperometry for glucose detection.

Main Results:

• Successfully synthesized NiO-HMSs with a porous nanoplate framework structure.
• Demonstrated excellent stability and high catalytic activity for glucose electro-oxidation in alkaline media.
• Achieved a wide linear response range (1.67 μM–6.87 mM), fast response time (3 s), low detection limit (0.53 μM), and high sensitivity (~2.39 mA mM⁻¹ cm⁻²).

Conclusions:

• The facile solvothermal method provides an effective route to NiO-HMSs.
• NiO-HMSs exhibit promising performance as non-enzymatic electrocatalysts for glucose sensing.
• The developed NiO-HMS-based biosensor shows excellent stability, sensitivity, and repeatability for practical glucose determination.