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Updated: May 5, 2026
Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells
Published on: October 27, 2009
Effect of gold nanoparticles coated with plasma components on ADP-induced platelet aggregation
A V Aseychev1, O A Azizova, E M Beckman
1Laboratory of Biophysical Bases of Pathology, Research Institute of Physicochemical Medicine, Russian Federal Medical Biological Agency, Moscow, Russia. aseychev@mail.ru.
Abstract:
We studied the effect of gold nanospheres coated with components of autologous blood plasma on ADP-induced platelet aggregation. Gold nanoparticles in the chosen concentration range (5-40 μM) and particle size (5-30 nm) with or without coating produced no activating effect on platelet aggregation caused by aggregation inductor ADP in all applied doses (1.6, 2.0, and 5.0 μM). Nanoparticles with a diameter of >60 nm inhibited platelet aggregation. These findings and published data confirm the biological safety of gold nanoparticles for targeted delivery of drugs and phototherapy.
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