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Updated: May 5, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Functional outcomes of very premature infants into adulthood
1Neonatal Follow-up Program, McMaster University, Hamilton, Ontario, Canada.
Insights
Most very low birth weight survivors lead productive lives, functioning better than anticipated. Long-term health monitoring is crucial for these individuals as they age.
Area of Science:
- Neonatalogy
- Developmental Pediatrics
- Longitudinal Studies
Background:
- Outcomes for very low birth weight (VLBW) survivors from the early neonatal intensive care era are now available into young adulthood.
- Longitudinal cohort studies and Scandinavian national databases provide insights into their long-term development.
- Previous findings indicate a majority of VLBW survivors lead productive lives, exceeding expectations despite disabilities.
Purpose of the Study:
- To summarize and analyze the long-term outcomes of very low birth weight survivors.
- To assess the functional status and life productivity of VLBW individuals into young adulthood.
- To identify ongoing concerns regarding the future health of VLBW survivors as they age.
Main Methods:
- Analysis of longitudinal cohort studies.
- Review of large Scandinavian national databases.
- Long-term follow-up of very low birth weight survivors into young adulthood.
Main Results:
- A significant majority of very low birth weight survivors are leading productive lives.
- VLBW survivors are functioning better than expected in young adulthood.
- Concerns remain regarding potential future psychopathology and cardiovascular/metabolic issues in middle age.
Conclusions:
- Current data on very low birth weight survivors offer reassurance about their functional outcomes.
- Long-term health surveillance is necessary to monitor for emerging issues in aging VLBW populations.
- While not directly applicable to modern neonatal care, these findings serve as a benchmark for future outcome projections.
Abstract:
The outcomes of very low birth weight survivors born in the early post-neonatal intensive care era have now been reported to young adulthood in several longitudinal cohort studies, and more recently from large Scandinavian national databases. The latter reports corroborate the findings that despite disabilities, a significant majority of very low birth weight survivors are leading productive lives, and are functioning better than expected. This is reassuring, but there are still concerns about future psychopathology, cardiovascular and metabolic problems as they approach middle age. Although these findings may not be directly applicable to the current survivors of modern neonatal intensive care, they do provide a yardstick by which to project the outcomes of future survivors until more contemporaneous data are available.
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