Related Experiment Video
Updated: May 5, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
Timed up and go, cognitive, and quality-of-life correlates in Parkinson's disease
Elizabeth L Stegemöller1, Joe Nocera2, Irene Malaty3
1Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL; Department of Kinesiology, Iowa State University, Ames, IA.
Objective:
To examine the relationship between Timed Up and Go (TUG) performance, verbal executive function (EF) performance, and quality-of-life (QOL) measures in Parkinson's disease (PD).
Design:
Cross-sectional.
Setting:
Sixteen movement disorder centers from across the United States.
Participants:
Patients with PD (N=1964).
Interventions:
Not applicable.
Main Outcome Measures:
TUG test, immediate and delayed 5-word recall, verbal fluency, PD QOL Questionnaire.
Results:
TUG performance and verbal EF performance were significantly associated with, and predictors of, QOL measures, having the greatest association and predictability with the mobility domain of the QOL measures.
Conclusions:
The TUG test and verbal EF tests have QOL correlates, making the combined evaluation of mobility, cognitive, and QOL decline a potential examination tool to evaluate the sequelae of PD.
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