Related Experiment Video
Updated: May 5, 2026
10:52
Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
Published on: December 23, 2022
7.8K
Patent ductus arteriosus closure using an Amplatzer(™) ventricular septal defect closure device
Rajeev Fernando1, Ketan Koranne, Pranav Loyalka
1University of Texas Health Science Center at Houston, Houston, Texas, USA.
Experimental and Clinical Cardiology
|December 3, 2013
Summary
Patent ductus arteriosus (PDA) is a heart condition that can cause heart failure. This case study shows a successful PDA closure in an adult using a device designed for ventricular septal defects.
Area of Science:
- Cardiology
- Medical Devices
- Congenital Heart Disease
Background:
- The ductus arteriosus is a fetal blood vessel that normally closes shortly after birth.
- Persistence of the ductus arteriosus results in patent ductus arteriosus (PDA), a condition rare in adults.
- PDA can lead to serious complications like heart failure and pulmonary hypertension.
Observation:
- A 35-year-old woman presented with congestive heart failure due to a large PDA.
- Transcatheter closure is the preferred treatment for PDA in adults, offering advantages over surgery.
- Designing effective PDA occluders is challenging due to anatomical variations.
Findings:
- A large PDA was successfully occluded using an Amplatzer muscular ventricular septal defect closure device.
- This approach highlights the potential adaptability of existing devices for PDA treatment.
- The device's design features, such as its wider waist and dual-retention discs, may be beneficial for large PDAs.
Implications:
- This case suggests that ventricular septal defect closure devices could be a viable option for treating large PDAs in adults.
- Further research into device design modifications could optimize outcomes for PDA occlusion.
- Successful transcatheter closure can significantly improve heart failure symptoms and reduce pulmonary pressures.
