Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

167
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
167
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

165
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
165
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

358
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
358
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.1K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.0K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Controlling nanoparticle targeting: from physicochemical design to molecular recognition.

Nanomedicine (London, England)·2026
Same author

Decoy Nanoparticles and Protein Corona Modulation: A Novel Frontier in Sepsis Treatment.

International journal of nanomedicine·2026
Same author

Oxidative cues as theranostic switches for the ROS-responsive Nanotheranostics in oxidative stress-driven diseases.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Botanical and Upcycled Bioactives for Advanced Topical Formulations: Mechanistic Pathways, Cutaneous Delivery, and Sustainability-by-Design.

Pharmaceutics·2026
Same author

PEG-β-Cyclodextrin polymer-based formulation to increase the antiangiogenic activity of rutin in vivo.

International journal of pharmaceutics·2026
Same author

Integrative Approaches to Treating Cellular Senescence in Kidney Disease.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Related Experiment Video

Updated: May 5, 2026

Using In Vitro Live-cell Imaging to Explore Chemotherapeutics Delivered by Lipid-based Nanoparticles
10:26

Using In Vitro Live-cell Imaging to Explore Chemotherapeutics Delivered by Lipid-based Nanoparticles

Published on: November 1, 2017

10.6K

Liposomal chemotherapeutics.

Emanuela Gentile1, Felisa Cilurzo, Luisa Di Marzio

  • 1Department of Health Sciences, University 'Magna Graecia' of Catanzaro, University Campus 'S. Venuta', Building of BioSciences, V.le 'S. Venuta' 88100 Germaneto - Catanzaro, Italy.

Future Oncology (London, England)
|December 4, 2013
PubMed
Summary
This summary is machine-generated.

Liposomes enhance chemotherapy by improving drug delivery, increasing efficacy, and reducing side effects. This review highlights liposomal gemcitabine and paclitaxel for treating various cancers.

More Related Videos

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

9.2K
Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

14.2K

Related Experiment Videos

Last Updated: May 5, 2026

Using In Vitro Live-cell Imaging to Explore Chemotherapeutics Delivered by Lipid-based Nanoparticles
10:26

Using In Vitro Live-cell Imaging to Explore Chemotherapeutics Delivered by Lipid-based Nanoparticles

Published on: November 1, 2017

10.6K
Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

9.2K
Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

14.2K

Area of Science:

  • Oncology
  • Pharmaceutics
  • Drug Delivery

Background:

  • Six liposomal chemotherapeutics are approved; many more are in development.
  • Liposomes offer low toxicity and improved drug properties, enhancing the therapeutic index.
  • Liposomal drug delivery systems are increasingly important in cancer treatment.

Purpose of the Study:

  • To review the advantages of liposomal drug delivery for chemotherapeutics.
  • To illustrate improvements in drug performance using gemcitabine and paclitaxel as examples.
  • To examine the benefits of liposomes in treating diverse solid and blood-borne tumors.

Main Methods:

  • Literature review of approved and investigational liposomal chemotherapeutics.
  • Analysis of case studies focusing on gemcitabine and paclitaxel.
  • Examination of clinical data on liposomal drug efficacy in various cancers.

Main Results:

  • Liposomal incorporation significantly improves the performance of unstable or poorly soluble drugs.
  • Liposomes increase drug efficacy and reduce side effects compared to conventional formulations.
  • Demonstrated benefits in treating thyroid, pancreatic, breast cancers, and multiple myeloma.

Conclusions:

  • Liposomal formulations represent a significant advancement in chemotherapy delivery.
  • Liposomes enhance the therapeutic potential of existing and novel chemotherapeutic agents.
  • Liposomal chemotherapy holds promise for improved patient outcomes across a range of malignancies.