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Updated: May 5, 2026
07:42
A Data-Driven Approach to Quantifying Immune States in Sepsis
Published on: February 7, 2025
599
Definitions and pathophysiology of sepsis
Mayer Sagy1, Yasir Al-Qaqaa, Paul Kim
1NYU Langone Medical Center, Division of Pediatric Critical Care Medicine, New York, NY.
Current Problems in Pediatric and Adolescent Health Care
|December 4, 2013
Summary
Sepsis and septic shock mortality rates remain high. This review covers sepsis pathophysiology, comorbidities like MODS and ARDS, and management strategies to improve patient outcomes.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Pathophysiology
Background:
- Sepsis and septic shock mortality rates have stagnated over the last decade.
- The Surviving Sepsis Campaign (SSC) guidelines advocate for prompt recognition and treatment.
- Reducing the global burden of sepsis remains a critical challenge.
Purpose of the Study:
- To review the pathophysiology of sepsis.
- To discuss common comorbidities associated with sepsis, including multiorgan dysfunction syndrome (MODS) and acute respiratory distress syndrome (ARDS).
- To outline current management strategies for sepsis and septic shock.
Main Methods:
- Literature review of existing studies and guidelines.
- Synthesis of information on sepsis pathophysiology.
- Analysis of comorbidities and their impact on sepsis management.
Main Results:
- Sepsis pathophysiology involves complex inflammatory and coagulation pathways.
- Comorbidities significantly complicate sepsis management and increase mortality risk.
- Early goal-directed therapy and appropriate antimicrobial use are crucial.
Conclusions:
- Improved understanding of sepsis pathophysiology is essential for developing novel therapies.
- Integrated management addressing comorbidities is vital for reducing sepsis-related mortality.
- Adherence to evidence-based guidelines can mitigate the impact of sepsis and septic shock.
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