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Cutaneous Notch signaling in health and disease
1Swiss Institute for Experimental Cancer Research (ISREC), Ecole Polytechnique Federale Lausanne (EPFL), Lausanne 1015, Switzerland.
Abstract:
The development and maintenance of the skin are dependent on myriad signaling pathways that regulate a variety of cellular processes. In cutaneous epithelial cells, the Notch cascade plays a central role in ensuring that proliferation and differentiation are coordinated appropriately, a function that it imparts during both ontogeny and homeostasis. Aberrations of the Notch signaling pathway result in severe abnormalities in the epidermis and its appendages and cause functional defects such as perturbed barrier function. In addition, impaired Notch signaling is associated with diseases of the skin such as atopy and cancer. The pathology associated with aberrant cutaneous Notch signaling reflects the complex mechanisms underpinning its function in this tissue and involves both cell-autonomous and nonautonomous mechanisms. This review summarizes our current knowledge of the role of Notch signaling in the skin during health and disease.
Insights
The Notch signaling pathway is crucial for skin development and health, coordinating cell growth and differentiation. Disruptions in this pathway lead to skin abnormalities and diseases like cancer.
Area of Science:
- Dermatology
- Cell Biology
- Molecular Signaling
Background:
- Skin development and maintenance rely on complex signaling pathways.
- The Notch cascade is vital for coordinating epithelial cell proliferation and differentiation.
- Proper Notch signaling ensures epidermal homeostasis and function.
Purpose of the Study:
- To review the role of Notch signaling in skin health and disease.
- To summarize current knowledge on Notch pathway mechanisms in cutaneous tissues.
- To highlight the impact of Notch signaling on epidermal development and homeostasis.
Main Methods:
- Literature review of studies on Notch signaling in skin.
- Analysis of research on Notch pathway aberrations and associated pathologies.
- Synthesis of information on cell-autonomous and nonautonomous mechanisms.
Main Results:
- Notch signaling is essential for coordinated proliferation and differentiation in the epidermis.
- Aberrant Notch signaling causes severe skin abnormalities, including epidermal defects.
- Impaired Notch signaling is linked to skin diseases such as atopy and cancer.
Conclusions:
- The Notch pathway plays a central role in skin homeostasis and development.
- Dysregulation of Notch signaling underlies various dermatological conditions.
- Understanding Notch signaling mechanisms is key to addressing skin diseases.
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