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Related Experiment Video

Updated: May 5, 2026

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Published on: March 15, 2019

The human IgE repertoire.

Elisabeth Gadermaier¹, Mattias Levin, Sabine Flicker

¹Division of Immunopathology, Department of Pathophysiology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

International Archives of Allergy and Immunology

|December 4, 2013

Summary

This summary is machine-generated.

This review explores the human immunoglobulin E (IgE) repertoire, crucial for allergies. Advances in sequencing are improving our understanding of IgE

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Last Updated: May 5, 2026

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Published on: March 15, 2019

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

Published on: January 12, 2021

Detection of True IgE-expressing Mouse B Lineage Cells

Detection of True IgE-expressing Mouse B Lineage Cells

Published on: December 1, 2014

Area of Science:

Immunology
Allergy Research
Antibody Engineering

Background:

Immunoglobulin E (IgE) is central to allergic diseases.
The human IgE repertoire's composition and activity remain poorly understood.
Low circulating IgE levels and rare IgE-producing B cells hinder research.

Purpose of the Study:

To summarize current knowledge on the human IgE repertoire's complexity and activity.
To highlight recent advancements despite research challenges.
To discuss future directions for IgE research.

Main Methods:

Review of existing literature on human IgE.
Analysis of challenges in studying IgE molecular details.
Exploration of emerging sequencing technologies and methodologies.

Main Results:

Recent years have seen increased knowledge acquisition on human IgE repertoires.
Despite difficulties, progress has been made in defining IgE complexity and activity.
New technologies promise further insights into IgE.

Conclusions:

Understanding the human IgE repertoire is critical for advancing allergy treatment.
Improvements in sequencing and isolation techniques will enhance knowledge of IgE.
Future research will likely deepen our comprehension of IgE's role in human disease.