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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Cyclodextrin-based nanosponges: a propitious platform for enhancing drug delivery.

Sai V Chilajwar1, Priti P Pednekar, Kisan R Jadhav

  • 1University of Mumbai, Bharati Vidyapeeth's College of Pharmacy, Department of Pharmaceutics , Sector 8, C B D Belapur, Navi Mumbai 400 614 , India +91 022 27571122 ; +91 022 27574525 ; krj24@rediffmail.com.

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Cyclodextrin-based nanosponges offer advanced drug delivery solutions, overcoming solubility issues common in pharmaceuticals. This nanotechnology promises improved formulations and targeted therapeutics for better patient outcomes.

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Pharmaceutical Sciences

Background:

  • Nanotechnology enhances drug delivery beyond conventional methods.
  • Cyclodextrin-based nanosponges address significant drug solubility challenges.
  • Approximately 40% of marketed and 90% of developmental drugs face solubility issues.

Purpose of the Study:

  • To provide an overview of cyclodextrin-based nanosponges.
  • To discuss their properties, preparation, and characterization.
  • To explore their application in drug formulation development.

Main Methods:

  • Review of physical and chemical properties.
  • Discussion of preparation and characterization techniques.
  • Analysis of biocompatibility and formulation strategies.

Main Results:

  • Cyclodextrin-based nanosponges offer advantages over traditional cyclodextrins.
  • These nanosponges can overcome drug solubility limitations.
  • Biocompatibility and formulation potential are key features.

Conclusions:

  • Cyclodextrin-based nanosponges represent a promising formulation technology.
  • This innovation is expected to yield successful pharmaceutical products.
  • Future applications include site-directed drug delivery and advanced therapeutics.