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Determination of galantamine hydrobromide in bulk drug and pharmaceutical dosage form by spectrofluorimetry
Amit V Patel1, Vishal J Patel, Avani V Patel
1Department of Quality Assurance, Shri Sarvajanik Pharmacy College, Near Aravind Baug, Mehsana, Gujarat, India.
Aim:
To develop a simple, accurate, sensitive, rapid and precise method for the determination of galantamine hydrobromide in bulk drug and pharmaceutical dosage form.
Material And Methods:
The method employs wavelength detection and determination of galantamine hydrobromide at excitation wavelength 282 nm and emission wavelength 607 nm in a solution of simple distilled water.
Result And Conclusion:
The method was found to be linear in the range of 2-14 μg/ml having r (2) = 0.9999. The mean accuracy was found to be 98.12% to 99.67%. The intraday and interday precision was found to be 0.18-0.35% and 0.13-0.46%, respectively. The limit of detection was found to be 0.29 μg/ml. The limit of quantification was found to be 0.89 μg/ml. The method was successfully applied for the determination of galantamine hydrobromide in bulk drug as well as pharmaceutical dosage form.
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