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Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
Published on: January 25, 2016
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Pseudoexfoliation syndrome and sensorineural hearing loss
Ramin Zojaji1, Ali Alesheykh, Mohammad Reza Sedaghat
1Department of otorhinolaryngology, Islamic Azad University, Medical branch, Mashhad, Iran.
Iranian Journal of Otorhinolaryngology
|December 5, 2013
Summary
Pseudoexfoliation syndrome (PXS) is significantly associated with sensorineural hearing loss (SNHL). This study found a higher prevalence of SNHL in PXS patients, supporting PXS as a systemic condition.
Area of Science:
- Ophthalmology
- Otorhinolaryngology
- Genetics
Background:
- Pseudoexfoliation syndrome (PXS) involves extracellular fibrillar material deposition in the anterior eye chamber.
- PXS is increasingly recognized as a systemic condition potentially affecting the inner ear, leading to sensorineural hearing loss (SNHL).
Purpose of the Study:
- To evaluate the prevalence of SNHL in Iranian patients with PXS.
- To compare findings with international reports on the association between PXS and SNHL.
Main Methods:
- A prospective case-control study involving 33 PXS patients and 33 matched controls.
- Ophthalmologic, otorhinolaryngologic examinations, and pure tone audiometry (PTA) at six frequencies were performed.
- Data analyzed using t-test and chi-square test.
Main Results:
- A significantly higher prevalence of SNHL was observed in the PXS group (75.2%) compared to controls (40.9%) (P<0.001).
- No significant association was found between exfoliative glaucoma (EXG) and SNHL within the PXS cohort (P=0.768).
Conclusions:
- The findings indicate a significant association between PXS and SNHL.
- These results support the hypothesis that PXS is a systemic disease with potential inner ear manifestations.
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