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Related Concept Videos

Classification of Skeletal Muscle Fibers01:48

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Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
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Semi-automated Analysis of Mouse Skeletal Muscle Morphology and Fiber-type Composition
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A pattern recognition approach to myopathy.

Carlayne E Jackson, Richard J Barohn

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    |December 6, 2013
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    Summary
    This summary is machine-generated.

    Diagnosing myopathies, a group of muscle disorders, can be difficult. This review offers a clinical approach to diagnosis, aiding in timely and cost-effective identification of these conditions.

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    Area of Science:

    • Neurology
    • Genetics

    Background:

    • Myopathies represent a diverse category of muscle disorders, often posing diagnostic challenges.
    • Recent advancements in genetic testing have improved diagnostic capabilities.

    Purpose of the Study:

    • To outline a diagnostic strategy for myopathies.
    • Emphasis on clinical history and neurologic examination for initial diagnosis.
    • Discussion of laboratory tests to confirm suspected diagnoses.

    Main Methods:

    • Pattern recognition based on clinical presentation.
    • Review of diagnostic approaches.
    • Integration of laboratory and genetic testing.

    Main Results:

    • Genetic testing has advanced myopathy diagnosis over the last decade.
    • High cost and insurance coverage issues limit widespread genetic testing access.

    Conclusions:

    • A systematic approach using clinical findings can lead to accurate and timely myopathy diagnoses.
    • This method can help reduce the need for expensive genetic testing.