Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

2.4K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
2.4K
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

269
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
269
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

209
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
209
Hypersensitivities01:30

Hypersensitivities

7.3K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.3K
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

23
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence...
23
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

280
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
280

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk Prediction Models for Sentinel Node Positivity in Melanoma: A Systematic Review and Meta-Analysis.

JAMA dermatology·2025
Same author

Severe atopic dermatitis treated with Dupilumab in a CTLA-4-deficient patient: A case report and review of the literature.

SAGE open medical case reports·2025
Same author

A case report of lupus panniculitis-induced facial lipoatrophy successfully treated with injectable hyaluronic acid.

SAGE open medical case reports·2024
Same author

Editorial: Methods in artificial intelligence for dementia 2024.

Frontiers in dementia·2024
Same author

A realist interview study of a participatory public mental health project "#KindnessByPost".

BMC public health·2023
Same author

Surveillance After a Previous Cutaneous Melanoma Diagnosis: A Scoping Review of Melanoma Follow-Up Guidelines.

Journal of cutaneous medicine and surgery·2023
Same journal

Exosomes in Dermatology.

Skin therapy letter·2026
Same journal

Zasocitinib: New Frontier in Tyrosine Kinase 2 Inhibition.

Skin therapy letter·2026
Same journal

Erratum to: Deuruxolitinib for Alopecia Areata.

Skin therapy letter·2026
Same journal

Advances in the Management of Hyperhidrosis.

Skin therapy letter·2026
Same journal

Topical Ruxolitinib for the Treatment of Hidradenitis Suppurativa.

Skin therapy letter·2026
Same journal

Icotrokinra: A Promising Oral IL-23 Receptor Inhibitor for Moderate-to-Severe Plaque Psoriasis.

Skin therapy letter·2026
See all related articles

Related Experiment Video

Updated: May 5, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

9.9K

Chronic urticaria and autoimmunity.

Kathleen Fraser1, Lynne Robertson

  • 1College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada; Section of Dermatology, Department of Medicine, University of Calgary, Calgary, AB, Canada.

Skin Therapy Letter
|December 6, 2013
PubMed
Summary
This summary is machine-generated.

Chronic urticaria, often autoimmune, is linked to other autoimmune diseases like thyroid issues. Understanding these connections can guide better treatments for chronic hives.

More Related Videos

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

7.8K
Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.9K

Related Experiment Videos

Last Updated: May 5, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

9.9K
Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

7.8K
Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.9K

Area of Science:

  • Immunology
  • Dermatology
  • Endocrinology

Background:

  • Chronic urticaria (CU) involves daily hives lasting over six weeks.
  • Chronic idiopathic urticaria (CIU) is the most common form, lacking external triggers.
  • Autoimmune mechanisms, particularly autoantibodies to the IgE receptor (FcεRI), are implicated in over half of CIU cases.

Purpose of the Study:

  • To review the associations between chronic urticaria and autoimmune disorders.
  • To explore the link between chronic urticaria and thyroid disease.
  • To discuss therapeutic implications of these autoimmune correlations.

Main Methods:

  • Literature review of studies on chronic urticaria and autoimmune diseases.
  • Analysis of the proposed autoimmune pathogenesis of chronic urticaria.
  • Examination of clinical associations and epidemiological data.

Main Results:

  • A significant association exists between chronic urticaria and various autoimmune diseases, including thyroid disease, rheumatoid arthritis, lupus, Sjögren's syndrome, celiac disease, and type 1 diabetes.
  • Autoimmune mechanisms are a key factor in a substantial portion of chronic idiopathic urticaria cases.
  • The predisposition to self-reactivity is a potential underlying factor in chronic urticaria.

Conclusions:

  • Chronic urticaria frequently co-occurs with other autoimmune conditions, notably thyroid disease.
  • Identifying autoimmune comorbidities is crucial for managing chronic urticaria.
  • These associations suggest potential therapeutic strategies targeting autoimmune pathways for chronic urticaria treatment.