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A Saline/Bipolar Radiofrequency Energy Device As an Adjunct for Hemostasis in Solid Organ Injury/Trauma
Published on: July 28, 2020
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Hemostatic strategies for traumatic and surgical bleeding
Adam M Behrens1, Michael J Sikorski, Peter Kofinas
1Fischell Department of Bioengineering, University of Maryland, 2330 Jeong H. Kim Engineering Building, College Park, Maryland, 20742.
Journal of Biomedical Materials Research. Part A
|December 6, 2013
Summary
New hemostatic agents are being developed to address limitations in safety, efficacy, and storage of current options. This review covers biologically derived, synthetically derived, and intravenously administered approaches, highlighting their mechanisms and advancements.
Area of Science:
- Biomaterials Science
- Medical Devices
- Pharmacology
Background:
- Current hemostatic agents present unmet needs in hospital and battlefield applications.
- Existing commercial hemostatic agents often fall short in safety, efficacy, cost, and storage requirements.
Purpose of the Study:
- To review and discuss the three major classes of hemostatic approaches.
- To detail specific hemostatic methods, their mechanisms, and advancements.
Main Methods:
- Literature review of biologically derived materials.
- Literature review of synthetically derived materials.
- Literature review of intravenously administered hemostatic agents.
Main Results:
- Biologically derived hemostats leverage natural materials for clotting.
- Synthetic hemostats offer tunable properties and improved stability.
- Intravenous agents provide systemic hemostasis through various mechanisms.
Conclusions:
- Advancements in hemostatic strategies are rapidly evolving.
- Understanding synthetic-biologic interactions is crucial for future developments.
- Novel hemostatic approaches are poised to replace current clinical methodologies.
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